DRUG IN ADHESIVE TRANSDERMAL SYSTEM OF FUROSEMIDE: IN VITRO IN VIVO EVALUATION

Objective: The objective of the present work aims to check effect penetration enhancers on release kinetics in a novel drug adhesive transdermal system furosemide. Methods: systems were evaluated for pharmacotechnical properties and vitro permeation through excised rat epidermis. Among DURO-TAKs screened studies. results quantified using RP-HPLC. optimized was subjected vivo kinetic studies New Zealand male rabbits. further tack skin irritation Results: DURO-TAK 2510 demonstrated best profile than 2852. A combination proved more be efficient alone, case F9 (IPM: PG 7.5:2.5) maximum (314.45±5.97 µg/cm2) observed by end study with flux 9.2052±0.33 μg/cm2/h. confirmed that controlled prolonged duration an extended AUC MRT decreased Cmax compared oral route, which can provide promising pharmacological DIA route. Conclusion: findings drugs enhance both bioavailability patient compliance development systems.